| 主权项 |
1. A recombinant combination vaccine composition comprising an isolated and/or recombinant first and a second polypeptide, wherein the first polypeptide consists of SEQ ID NO: 60 or consists of SEQ ID NO: 60 having one or more point mutations selected from the group consisting of:
L at amino acid position 70 replaced with V, A at amino acid position 152 replaced with G, Y at amino acid position 382 replaced with N, and I at amino acid position 436 replaced with M; and wherein said second polypeptide consists of SEQ ID NO: 64 or consists of SEQ ID NO: 64 having one or more point mutations selected from the group consisting of: S at amino acid position 8 replaced with N, E at amino acid position 163 replaced with K, K at amino acid position 172 replaced with E, E at amino acid position 298 replaced with V, and G at amino acid position 340 replaced with D; or wherein said second polypeptide consists of SEQ ID NO: 36 or consists of SEQ ID NO: 36 having one or more point mutations selected from the group consisting of: S at amino acid position 9 replaced with N, E at amino acid position 164 replaced with K, K at amino acid position 173 replaced with E, E at amino acid position 299 replaced with V, and G at amino acid position 341 replaced with D; and an immunologically effective amount of an adjuvant. |
