| 发明名称 |
APTAMERS FOR TUMOR INITIATING CELLS |
| 摘要 |
Aptamers consisting of a single stranded nucleic acids having 100 nucleotides or less that specifically binds to tumor initiating cancer cells are described. The aptamers can be identified by screening a large pool of randomly generated aptamers to obtain a discrete set of aptamers that specifically bind to tumor initiating cancer cells, such as those found in brain cancer or glioblastoma. The aptamers can also be linked or complexed with anticancer agents or imaging agents for use in therapy or diagnosis. |
| 申请公布号 |
US2015366996(A1) |
申请公布日期 |
2015.12.24 |
| 申请号 |
US201414763283 |
申请日期 |
2014.02.04 |
| 申请人 |
THE CLEVELAND CLINIC FOUNDATION |
发明人 |
Rich Jeremy N.;Kim Youngmi;Hjelmeland Anita B. |
| 分类号 |
A61K47/48;G01N33/574;A61K47/10;C12N15/115;A61K49/00 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An aptamer consisting of a single stranded nucleic acid having 100 nucleotides or less that specifically binds to tumor initiating cancer cells. |
| 地址 |
Cleveland OH US |
