The present disclosure generally relates to inhibitors of the PD-l/PD- Ll protein/protein and CD80/PD-L1 protein/protein interactions useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.
申请公布号
WO2015160641(A3)
申请公布日期
2015.12.23
申请号
WO2015US25249
申请日期
2015.04.10
申请人
BRISTOL-MYERS SQUIBB COMPANY
发明人
CHUPAK, LOUIS S.;DING, MIN;MARTIN, SCOTT W.;ZHENG, XIAOFAN;HEWAWASAM, PIYASENA;CONNOLLY, TIMOTHY P.;XU, NINGNING;YEUNG, KAP-SUN;ZHU, JULIANG;LANGLEY, DAVID R.;TENNEY, DANIEL J.;SCOLA, PAUL MICHAEL