Agonists of Src homology-2 containing protein tyrosine phosphatase-1 and treatment methods using the same

摘要

The present invention provides new compounds of formula I, II or III, which have Src homology-2 containing protein tyrosine phosphatase-1 (SHP-1) agonist activity. Also provided are treatment methods using the compounds of formula I, II or III.

主权项

1. A compound which is represented by Formula II(b) or II(c) wherein R4, R5 and R6 are independently hydrogen, hydroxyl, optionally substituted alkoxyl, optionally substituted thioalkoxy, optionally substituted lower alkenyl, optionally substituted low alkynyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroarakyl, —(C)qNHS(O)2Rc, or —(C)r(X)NHRd; wherein at least one R4, R5, or R6 is not hydrogen; wherein Rc, and Rd are independently hydrogen, halo, hydroxyl, optionally substituted alkoxyl, optionally substituted thioalkoxy, optionally substituted alkyl, optionally substituted lower alkenyl, optionally substituted low alkynyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroarakyl; X=O or S; and q, r=0, 1, or 2.