| 发明名称 | LprG as a chaperone of immune adjuvants | ||
| 摘要 | An adjuvant combination that stimulates immune activation or response includes a hydrophobic immune adjuvant and a pathogen derived lipoprotein that chaperones the hydrophobic immune adjuvant to an immune receptor. | ||
| 申请公布号 | US9216216(B2) | 申请公布日期 | 2015.12.22 |
| 申请号 | US201514798000 | 申请日期 | 2015.07.13 |
| 申请人 | Case Western Reserve University | 发明人 | Harding Clifford;Boom W. Henry;Drage Michael G.;Pecora Nicole D. |
| 分类号 | A61K39/00;A61K39/39 | 主分类号 | A61K39/00 |
| 代理机构 | Tarolli, Sundheim, Covell & Tummino LLP | 代理人 | Tarolli, Sundheim, Covell & Tummino LLP |
| 主权项 | 1. A vaccine comprising: an antigen; a hydrophobic immune adjuvant; and purified non-acylated or acylated Mycobacterium tuberculosis LprG lipoprotein in an amount effective to chaperone the immune adjuvant to an immune receptor, the hydrophobic immune adjuvant being a glycolipid immune adjuvant. | ||
| 地址 | Cleveland OH US | ||