Means for controlled sealing of endovascular devices

摘要

Expandable sealing means for endoluminal devices have been developed for controlled activation. The devices have the benefits of a low profile mechanism (for both self-expanding and balloon-expanding prostheses), contained, not open, release of the material, active conformation to the “leak sites” such that leakage areas are filled without disrupting the physical and functional integrity of the prosthesis, and on-demand, controlled activation, that may not be pressure activated.

主权项

1. An endoluminal seal for sealing an endoluminal implant or prosthesis to a wall of a lumen of a subject, the endoluminal seal comprising:
an expandable material selected from the group consisting of hydrogels and foams, wherein the expandable material is expanded upon exposure to a fluid or a foaming agent, a semi-permeable first membrane adjacent to and encapsulating the expandable material, and an impermeable second membrane, metal foil or laminate preventing fluid or foaming agent from penetrating the semi-permeable first membrane to contact the expandable material prior to activation.