发明名称 |
IGF-1 FUSION POLYPEPTIDES AND THERAPEUTIC USES THEREOF IGF-1 |
摘要 |
<p>A fusion protein comprising at least one IGF1 variant component and a fusion component (F), and, optionally, a signal sequence, exhibiting improved stability relative to the native IGF1 or IGF2 polypeptide. The fusion component (F) may be a multimerizing component, a targeting ligand, or another active or therapeutic compound. IGF1 variants were shown to have improved ability to induce skeletal muscle hypertrophy relative to native IGF1.</p> |
申请公布号 |
HK1144684(A1) |
申请公布日期 |
2015.12.18 |
申请号 |
HK20100110734 |
申请日期 |
2010.11.18 |
申请人 |
REGENERON PHARMACEUTICALS INC. |
发明人 |
GLASS, DAVID, J.;YANCOPOULOS, GEORGE, D.;G DALY, THOMAS, J.;PAPADOPOULOS, NICHOLAS, J. |
分类号 |
C07K;A61K;A61P |
主分类号 |
C07K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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