主权项 |
1. A compound of formula (I), or a pharmaceutically acceptable salt thereof:whereinR1 is CH3 or halo;R2, R3 and R4 are H;R5 is CH3 or halo;R6 is selected from the group consisting of C3-5alkyl and —CH2—C3-4cycloalkyl;R7 is selected from the group consisting ofR8 is selected from the group consisting of C1-3alkyl, C1-3alkoxy, CH2CN, CH2OH, OH, CN and halo;R9 is the group —(CHR10)s—(X)t—(CHR10)u—R11;each R10 is independently selected from the group consisting of H, OH or CH2OH;R11 is —C(O)OH, or a 5- or 6-membered heteroaryl group optionally substituted with one or two substituents selected from halo, NH2 or CH3;X is CH2, NH, O;r is 0, 1 or 2;s is 0, 1 or 2;t is 0 or 1;u is 0, 1 or 2;with the proviso that no more than two R10 groups represent OH or CH2OH. |