NOVEL TRH BINDING SITE IN HUMAN CNS

摘要

The invention relates to a novel thyrotropin releasing hormone (TRH) receptor subtype in human central nervous system (CNS) that is pharmacologically distinct from the TRH receptor subtype in human pituitary. The invention provides a means to understand how the central actions of TRH are mediated and to isolate and characterise the novel receptor, as well as methods applicable to research and development of diagnostic and therapeutic applications in human CNS disorders.

主权项

1. A method of detecting a human central nervous system (CNS) TRH receptor subtype in a tissue, the method comprising incubating a tissue sample suspected of comprising the TRH receptor subtype with a compound having the structure:
Glp-W-Pro-X wherein X represents residues of from 1 to 20 amino acids, which may be in the L- or D configuration, the C-terminal amino-acid residue optionally being substituted with an amino group or aminomethyl coumarin (AMC), and W represents a natural or un-natural or amino-acid, and detecting any compound bound to the tissue sample.