Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.
申请公布号
WO2015191922(A1)
申请公布日期
2015.12.17
申请号
WO2015US35425
申请日期
2015.06.11
申请人
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;TOKITAE LLC