Method for Differentiating Sepsis and Systemic Inflammatory Response Syndrome (SIRS)

摘要

A method of characterizing sepsis in a subject involves determining an amount in a biological sample from the subject of each biomarker in a biomarker panel including at least two biomarkers; and calculating a risk index or sepsis probability score using the amounts of biomarkers in the biomarker panel. Exemplary biomarker panels include TNF-alpha, interleukin-6, interleukin-10, lipopolysaccharide binding protein, and C-reactive protein; IL-1beta, procalcitonin, absolute neutrophil count, and immature granulocyte count; and Interleukin-8, GM-CSF, MCP1, and INF-gamma. The method can further involve determining one or more clinical parameters about the subject, and calculating the risk index using the amounts of the biomarkers in the biomarker panel and the clinical parameters.

主权项

1. A method of characterizing sepsis in a subject, comprising:
determining an amount in a biological sample from the subject of each biomarker in a biomarker panel, wherein the biomarker panel comprises at least two of the biomarkers as set forth in Tables 1A, 1B, and 1C; and calculating a risk index using the amounts of the at least two biomarkers.