发明名称 |
SOLID FORMS OF AN ANTIVIRAL COMPOUND |
摘要 |
Crystalline solid forms of methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate (Compound I) were prepared and characterized in the solid state:;;Also provided are processes of manufacture and methods of using these crystalline forms. |
申请公布号 |
US2015361085(A1) |
申请公布日期 |
2015.12.17 |
申请号 |
US201514733101 |
申请日期 |
2015.06.08 |
申请人 |
Gilead Pharmasset LLC |
发明人 |
Lapina Olga Viktorovna;Shi Bing;Wang Fang;Wolckenhauer Scott Alan |
分类号 |
C07D491/052 |
主分类号 |
C07D491/052 |
代理机构 |
|
代理人 |
|
主权项 |
1. Crystalline methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate (Compound I Form I) characterized by an X-ray powder diffractogram comprising the following peaks: 4.8, 5.2, and 6.0 °2θ±0.2 °2θ, as determined on a diffractometer using Cu—Kα radiation at a wavelength of 1.5406 Å. |
地址 |
Foster City CA US |