| 发明名称 |
METHODS OF MODULATING DLK STABILITY |
| 摘要 |
The invention provides for methods of decreasing dual leucine zipper kinase (DLK) stability in a neuron, or decreasing or inhibiting the phosphorylation of certain amino acid residues of DLK, comprising administering to a neuron, or portion thereof, an agent which decreases or inhibits the phosphorylation of DLK and decreases the stability of DLK as well as methods for inhibiting or preventing neuronal degeneration in a patient by administering to a patient an agent which inhibits phosphorylation of dual leucine zipper kinase (DLK). |
| 申请公布号 |
US2015361184(A1) |
申请公布日期 |
2015.12.17 |
| 申请号 |
US201514839813 |
申请日期 |
2015.08.28 |
| 申请人 |
GENENTECH, INC. |
发明人 |
BUSTOS Daisy;HUNTWORK-RODRIGUEZ Sarah;KIRKPATRICK Donald;LEWCOCK Joseph Wesley;GHOSH Arundhati Sengupta |
| 分类号 |
C07K16/40;C12N15/113;A61K31/7052;A61K45/06;A61K39/395;G01N33/573;A61K38/02 |
主分类号 |
C07K16/40 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for decreasing dual leucine zipper kinase (DLK) stability in a neuron comprising administering to a neuron, or portion thereof, an agent which decreases or inhibits the phosphorylation of DLK and decreases the stability of DLK. |
| 地址 |
South San Francisco CA US |
