发明名称 |
METHODS AND MARKER COMBINATIONS FOR SCREENING FOR PREDISPOSITION TO LUNG CANCER |
摘要 |
The present invention relates to rapid, sensitive methods for determining whether a subject has or is at risk of devel-oping lung cancer based on certain combinations of biomarkers, or biomarkers and biometric parameters. The methods consist of: a) quantifying in a test sample obtained from a subject, the amount of two or more biomarkers in a panel, the panel comprising at least one antibody and at least one antigen: b) comparing the amount of each biomarker quantified in the panel to a predetermined cutoff for said biomarker and assigning a score for each biomarker based on said comparison: c) combining the assigned score for each biomarker quantified in step b to obtain a total score for said subject: d) comparing the total score in step c with a predetermined total score and e) determining whether said subject has a risk of lung cancer based on the comparison in step d. |
申请公布号 |
CA2691852(A1) |
申请公布日期 |
2009.01.08 |
申请号 |
CA20082691852 |
申请日期 |
2008.06.27 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
COLPITTS, TRACEY;RUSSELL, ERIC L.;FROST, STEPHEN;RAMIREZ, JAVIER;SINGH, BHAWANI;RUSSELL, JOHN C. |
分类号 |
C07K14/47;C07K16/18;C40B30/04;C40B40/10;G01N33/574 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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