发明名称 |
CRYSTALLINE MICROPOWDER PARTICLES |
摘要 |
<p>Crystalline particles of N-(17-cyclopropylmethyl-4,5±-epoxy-3,14-dihydroxy-morphinan-6²-yl)-phthalimide or a pharmaceutically acceptable salt thereof are disclosed. The crystalline particles have a particle diameter distribution in which a particle diameter (D50) at the point where cumulative frequency of volume distribution cumulatively calculated from particles having a smaller diameter reaches 50% is within a range of 1 to 30 µm, and a particle diameter (D90) at the point where cumulative frequency of volume distribution cumulatively calculated from particles having a smaller diameter reaches 90% is not more than 90 µm, which crystalline particles have a degree of crystallinity of not less than 80%. By the crystalline particles, bioavailability of the active substance may be increased while ensuring storage stability of the compound.</p> |
申请公布号 |
EP2156837(A1) |
申请公布日期 |
2010.02.24 |
申请号 |
EP20080752990 |
申请日期 |
2008.05.20 |
申请人 |
TORAY INDUSTRIES, INC.;ANDO, AKIHIRO |
发明人 |
AKIMOTO, MASAHIRO;KOMAGATA, TOSHIKAZU;SHIRAKI, MOTOHIRO;ANDO, AKIHIRO |
分类号 |
A61K31/485;A61K9/16;A61K9/20;A61P13/10;A61P17/04;A61P25/04;C07D489/08 |
主分类号 |
A61K31/485 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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