发明名称 |
NOVEL PHOTOSENSITIZER BASED ON POLYMER DERIVATIVES-PHOTOSENSITIZER CONJUGATES FOR PHOTODYNAMIC THERAPY |
摘要 |
<p>Disclosed is a novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy capable of being selectively accumulated in cancerous tissues and producing singlet oxygen or free radical by laser irradiation. The polymer derivatives-photosensitizer conjugates for photodynamic therapy are prepared as nano-sized particles, and have excellent selection and accumulation ratio for cancerous tissues. The photosensitizer conjugates can produce singlet oxygen or free radical by a specific laser wavelength. Owing to the excellent selection and accumulation ratio for cancerous tissues, the conjugates minimizes photo-cytotoxicity of the conventional photosensitizer having a low molecular amount. Accordingly, the conjugates are very useful as a photosensitizes for photodynamic therapy with reduced side effects and excellent therapeutic effectiveness.</p> |
申请公布号 |
EP2150278(A1) |
申请公布日期 |
2010.02.10 |
申请号 |
EP20080741523 |
申请日期 |
2008.04.23 |
申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
KWON, ICK-CHAN;CHOI, KUI-WON;KIM, KWANG-MEYUNG;YOUN, IN-CHAN;KIM, JONG-HO;PARK, KYEONG-SOON |
分类号 |
A61K49/12;A61K41/00;A61K47/48;A61P35/00 |
主分类号 |
A61K49/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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