发明名称 |
POLYMORPHISM IN TRYPTOPHAN HYDROXYLASE-2 CONTROLS BRAIN SEROTONIN SYNTHESIS |
摘要 |
A method of treating a subject for a serotonergic neurotransmission dysregulation disorder, comprises administering the subject a serotonin enhancer (e.g., a serotonin reuptake inhibitor) in an amount effective to treat the disorder; and concurrently administering the subject 5-hydroxytryptophan in an amount effective to enhance the activity of the serotonin enhancer, (e.g., serotonin reuptake inhibitor). In preferred embodiments the disorder is depression, anxiety, or substance abuse. |
申请公布号 |
EP1751312(A4) |
申请公布日期 |
2010.01.27 |
申请号 |
EP20050779990 |
申请日期 |
2005.05.20 |
申请人 |
DUKE UNIVERSITY |
发明人 |
CARON, MARC G.;ZHANG, XIAODONG;BEAULIEU, MARTIN;GAINETDINOV, RAUL R.;SOTNIKOVA, TATIANA D.;KRISHNAN, RANGA R.;SCHWARTZ, DAVID A.;BURCH, LAURANELL;WILLIAMS, REDFORD B. |
分类号 |
C12Q1/68;A01N37/18;A61K31/13;A61K31/14;C07K1/00;C07K16/00;C12N15/00;C12P21/06 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|