发明名称 |
PROCESS FOR THE PRODUCTION OF 2-[4-(3- OR 2-FLUOROBENZYLOXY)BENZYLAMINO]PROPANAMIDES WITH HIGH PURITY DEGREE |
摘要 |
A process for obtaining therapeutically active 2-[4-(3- and 2-(flurobenzyloxy)benzylamino]propanamides, and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight. The process is carried out by submitting the Schiff bases intermediates 2- [4 -(3- and 2-fluorobenzyloxy)benzylideneamino]propanamides to a reduction reaction with a reducing agent selected from sodium borohydride and potassium borohydride in an appropriate amount of an organic solvent selected from C1-C5 lower alkanols, allowing the formation and presence during a substantial position of the reduction reaction course of a suspension of the Schiff base into the saturated solution of the Schiff base into the same organic solvent. |
申请公布号 |
CA2706789(A1) |
申请公布日期 |
2009.06.18 |
申请号 |
CA20082706789 |
申请日期 |
2008.12.01 |
申请人 |
NEWRON PHARMACEUTICALS S.P.A. |
发明人 |
BARBANTI, ELENA;FARAVELLI, LAURA;SALVATI, PATRICIA;CANEVOTTI, RENATO;PONZINI, FRANCESCO |
分类号 |
C07C231/12;A61K31/165;A61P25/00;C07C237/08;C07C251/24 |
主分类号 |
C07C231/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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