| 摘要 |
1,193,700. 1 - oxa - 2 - oxo - 3,8 - diazaspiro- (4,5) - decanes. SCIENCE UNION ET CIE, SOC. FRACAISE DE RECHERCHE MEDICALE. 23 Dec., 1968 [29 Dec., 1967], No. 58994/67. Addition to 1,100,281. Heading C2C. Novel compounds of formula and acid addition salts thereof wherein R is either a radical of formula Ar<SP>1</SP>-(CH 2 ) 2 - where Ar<SP>1</SP> is 2-pyridyl, 4-pyridyl or is phenyl substituted by nitro, amino, acetamido, propionamido, benzamido, p-chlorobenzamido, o-hydroxybenzamido, methylsulphonamido, sulphamyl or dimethyl or diethyl-, sulphamyl or R is a radical of formula Ar-X-(CH 2 ) n - where n is 1, 2 or 3 and X is carbonyl, -CH(OH)-, -CH(OCH 3 )- or and Ar is phenyl optionally substituted by one or two halogen atoms, are prepared by reaction of a compound of formula and a compound of formula R-Z where Z is a chlorine or bromine atom optionally followed by salt formation. Pharmaceutical compositions in conventional forms for oral, rectal and parenteral administration having bronchodilator, analgesic, antiinflammatory and central nervous system depressant activity comprises an above novel compound or salt and a carrier therefor.
|
