发明名称 |
EMULSION-TYPE EXTERNAL PREPARATION, AND METHOD FOR PRODUCTION THEREOF |
摘要 |
<p>Disclosed are: an emulsion-type external preparation in which the precipitation of crystals of an alkali metal salt or an alkali earth metal salt of a carboxylic acid-type pharmaceutical active ingredient compound or a hydrate of the salt can be prevented effectively, which is mildly irritative, and in which the decrease in the content of the active ingredient can be prevented; and a method for producing the emulsion-type external preparation. Specifically disclosed are: an emulsion-type external preparation produced by mixing an emulsion and a treated acidic water-soluble polymer solution, wherein the emulsion is produced by emulsifying thefollowing components (a) and (b): (a) an aqueous phase comprising a pharmaceutical active ingredient compound having a carboxylate group and taking the form of an alkali metal salt or an alkali earth metal salt and an aqueous solvent; and (b) an oily phase comprising at least one oily component selected from the group consisting of a fatty acid ester, a hydrocarbon, an animal or plant oil, a hydrogenated oil thereof and a natural wax, and wherein the treated acidic water-soluble polymer solution is prepared by treating the whole or a part of an acidic water-soluble polymer with a basic substance in an aqueous solvent; and a method for producing the emulsion-type external preparation. Also specifically disclosed are: an emulsion-type external preparation produced by mixing an emulsified composition comprising a pharmaceutical active ingredient compound having a carboxylate group and taking the form of an alkali metal salt or an alkali earth metal salt with a solution comprising an acidic water-soluble polymer treated with a basic substance; and a method for producing the emulsion-type external preparation.</p> |
申请公布号 |
WO2009028650(A1) |
申请公布日期 |
2009.03.05 |
申请号 |
WO2008JP65501 |
申请日期 |
2008.08.29 |
申请人 |
YUTOKU PHARMACEUTICAL INDUSTRIES CO., LTD.;TANOUE, YASUHISA;DOI, SHIGEO;TAKAHASHI, TETSURO |
发明人 |
TANOUE, YASUHISA;DOI, SHIGEO;TAKAHASHI, TETSURO |
分类号 |
A61K9/107;A61K31/192;A61K31/196;A61K47/06;A61K47/10;A61K47/14;A61K47/18;A61K47/32;A61K47/46;A61P29/00 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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