COMPOSITIONS OF ASYMMETRIC INTERFERING RNA AND USES THEREOF
摘要
The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5 '-overhang, 3 '-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
申请公布号
WO2009029688(A2)
申请公布日期
2009.03.05
申请号
WO2008US74528
申请日期
2008.08.27
申请人
BOSTON BIOMEDICAL, INC.;LI, CHIANG, JIA;SUN, XIANGAO;ROGOFF, HARRY;LI, YOUZHI