ESCHERICIA COLI MUTANTS AND METHODS OF USE THEREOF

摘要

The present invention provides methods and compositions for production of gram- negative bacterial mutants that are defective in intestinal colonization capacity and sensitive to infection by bacteriophage Pl. Thus the present invention provides immunogenic compositions for the prevention or attenuation of food- and water-borne illnesses associated with ingestion of bacteria such as enterohemorrhagic Escherichia coli.