发明名称 |
POLYMERIC NANOPILLARS AND NANOTUBES, THEIR MANUFACTURE AND USES |
摘要 |
<p>A method is disclosed for fabricating free-standing polymeric nanopillars or nanotubes with remarkably high aspect ratios. The nanopillars and nanotubes may be used, for example, in integrated microfluidic systems for rapid, automated, high-capacity analysis or separation of complex protein mixtures or their enzyme digest products. One embodiment, preferably fabricated entirely from polymer substrates, comprises a cell lysis unit; a solid- phase extraction unit with free-standing, polymeric nanostructures; a multi-dimensional electrophoretic separation unit with high peak capacity; a solid-phase nanoreactor for the proteolytic digestion of isolated proteins; and a chromatographic unit for the separation of peptide fragments from the digestion of proteins. The nanopillars and nanotubes may also be used to increase surface area for reaction with a solid phase, for example, with immobilized enzymes or other catalysts within a microchannel, or as a solid support for capillary electrochromatography -based separations of proteins or peptides.</p> |
申请公布号 |
WO2008097360(A3) |
申请公布日期 |
2008.12.24 |
申请号 |
WO2007US78255 |
申请日期 |
2007.09.12 |
申请人 |
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE;SOPER, STEVEN, A.;MCCARLEY, ROBIN, L.;CHEN, GUOFANG;SHADPOUR, HAMED |
发明人 |
SOPER, STEVEN, A.;MCCARLEY, ROBIN, L.;CHEN, GUOFANG;SHADPOUR, HAMED |
分类号 |
B82B3/00;G01N33/50;G01N37/00 |
主分类号 |
B82B3/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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