| 摘要 |
<p>1,229,519. Quinoxaline derivatives. FARBENFABRIKEN BAYER A.G. 15 Aug., 1969 [30 Aug., 1968], No. 40859/69. Heading C2C. Novel quinoxaline derivatives of the formula in which R 1 is H, Cl, C 1-4 alkyl or C 1-4 alkoxy, R 2 and R 3 , which may be the same or different, are H or an aliphatic radical, which may be substituted by OH, C 1-4 alkoxy, carbalkoxy, or mono- or di-alkylamino, or are both alkylene and together with the N atom to which they are attached form a 5, 6 or 7 heterocyclic ring optionally containing a further N or O atom, and R 4 is H, C 1-4 alkyl or optionally substituted phenyl, are prepared by reacting the appropriate 2-chloro (or bromo) methyl-3-carbonamido-quinoxaline-di-N-oxide with the correspondingα-hydroxycarboxylic acid salts of the formula in which M# is Na#, K#, NH 4 # or trialkylammonium cation, in organic solvents or diluents at temperatures of between 10‹ and 160‹ C. Pharmaceutical compositions, suitable for oral or parenteral administration and having antibacterial activity, contain the above novel compounds as active ingredients in admixture with suitable pharmaceutically acceptable diluents or carriers. The active compounds may also be mixed with animal feed stuffs.</p> |
