发明名称 |
RNAi-mediated inhibition of ocular targets |
摘要 |
RNA interference is provided for inhibition of ocular hypertension target mRNA expression for lowering elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Ocular hypertension targets include carbonic anhydrase II, IV, and XII; beta1- and beta2 adrenergic receptors; acetylcholinesterase; Na+/K+-ATPase; and Na-K-2Cl cotransporter. Ocular hypertension is treated by administering interfering RNAs of the present invention.
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申请公布号 |
US7592324(B2) |
申请公布日期 |
2009.09.22 |
申请号 |
US20060345361 |
申请日期 |
2006.02.01 |
申请人 |
ALCON, INC. |
发明人 |
SHEPARD ALLAN R.;CHATTERTON JON E.;CLARK ABBOT F.;WAX MARTIN B. |
分类号 |
A61K31/70;C07H21/02;C07H21/04;C12N5/00;C12N15/113;C12Q1/68 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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