发明名称 |
Polyene Antibiotics, Compositions Containing Said Antibiotics, Method and Micro-Organisms Used to Obtain Same and Applications Thereof |
摘要 |
The invention relates to novel polyenes having formula (I), wherein: R1 represents alkyl C1-C3; and R2 represents a functional group selected from CH3- or CONH2- (methyl- or primary amide-). The aforementioned polyenes have a biocide action on organisms comprising cell membranes that contain ergosterol, e.g., fungi or parasites. Said compounds can be obtained using a method that consists in cultivating a producing micro-organism under conditions that enable the production thereof. In addition, the invention also relates to a mechanism for the in vitro production of amidated polyenes, consisting in incubating carboxylated polyenes with cell-free extracts (or proteinaceous fractions) of the producers of same in the presence of ATP/Mg++ and an amide- group donor compound (preferably glutamine).
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申请公布号 |
US2009221520(A1) |
申请公布日期 |
2009.09.03 |
申请号 |
US20060886673 |
申请日期 |
2006.03.23 |
申请人 |
MALPARTIDA ROMERO FRANCISCO;SECO MARTIN ELENA MARIA;CUESTA VELASCO TRINIDAD |
发明人 |
MALPARTIDA ROMERO FRANCISCO;SECO MARTIN ELENA MARIA;CUESTA VELASCO TRINIDAD |
分类号 |
A61K31/7048;A01N43/24;A01P3/00;C07H17/08;C12N1/21;C12N15/63;C12N15/74;C12P19/62 |
主分类号 |
A61K31/7048 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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