发明名称 |
FIBROBLAST GROWTH PATTERNS FOR DIAGNOSIS OF ALZHEIMER'S DISEASE |
摘要 |
Methods of diagnosing Alzheimer's disease are provided. At least five methods of diagnostic measurements are presented: Method 1: Integrated score; Method 2: Average aggregate area per number of aggregates; Method 3: Cell migration analysis; Method 4; Fractal analysis; Method 5: Lacunarity Analysis. In certain embodiments, a sample of a subject's skin provides a network of fibroblasts that is imaged and a fractal dimension of the image is calculated. The fractal dimension can be compared to an aged-matched control (non-Alzheimer's) database to determine if the subject has Alzheimer's disease. The network of fibroblasts may be cultured in a matrix, for example in a protein mixture.
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申请公布号 |
US2011136144(A1) |
申请公布日期 |
2011.06.09 |
申请号 |
US20100896862 |
申请日期 |
2010.10.02 |
申请人 |
CHIRILA FLORIN VALENTIN;KHAN TAPAN KUMAR;ALKON DANIEL L |
发明人 |
CHIRILA FLORIN VALENTIN;KHAN TAPAN KUMAR;ALKON DANIEL L. |
分类号 |
G01N33/567;C12Q1/02;C40B40/02 |
主分类号 |
G01N33/567 |
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