METHOD FOR SYNTHESIS OF TRITIUM-LABELLED 2-PHENYL SUBSTITUTED ISOQUINOLINE DERIVATIVES

摘要

FIELD: chemistry. ^ SUBSTANCE: present invention relates to a method for synthesis of tritium-labelled 2-phenyl substituted isoquinoline derivatives of general formula: , according to which isoquinoline undergoes a reaction for direct phenylation of a nitrogen atom with nucleogenic free phenyl cations. The source of pheny cations is a hexane solution twice titrated with benzene and the process is carried out in a closed system in the presence of a strong stabilising anion of potassium tetrafluoroborate. ^ EFFECT: novel single-step method for synthesis of tritium-labelled 2-phenyl substituted isoquinoline derivatives. ^ 1 cl, 1 ex