HETEROCYCLIC DERIVATIVES

摘要

PURPOSE: A heterocycle derivative used in manufacturing a medicine for treating uric acid-associated diseases is provided to ensure selectivity between organic anion transporters and high solubility and metabolic stability. CONSTITUTION: A heterocycle derivative compound has a structure of chemical formula I. A method for preparing a compound of chemical formula II or racemic body, isomer or pharmaceutically acceptable salt thereof comprises: a step of reducing a compound of chemical formula VII to obtain a compound of chemical formula VI; a step of cyclizing the compound of chemical formula VI and a compound of chemical formula V to obtain a compound of chemical formula IV; and a step of performing peptide bond of the compound of chemical formula IV and a compound of chemical formula III to obtain a compound of chemical formula II. A pharmaceutical composition contains the heterocycle derivative compound or racemic body, isomer or pharmaceutically acceptable salt thereof and pharmaceutically acceptable carrier. The pharmaceutical composition is formulated in oral administration.