摘要 |
Novel biotin analogues, such as 2-Azidobiotin, comprising the ureido ring of natural biotin with the thiophene ring, optionally modified, and a modified sidechain having a functional end group, preferably selected from the group consisting of a carboxylic acid, amine, alcohol, thiol, aldehyde and a halide, and at least one bio- orthogonally reactive chemical group located elsewhere in the sidechain. The analogues are used for labelling target structures and biomolecules, such as peptides and proteins in vitro or in vivo. |
申请人 |
UNIVERSITY OF NOTTINGHAM;NEIL, THOMAS, R;YONG-QING, YANG;DREWE, WILLIAM C |
发明人 |
NEIL, THOMAS, R;YONG-QING, YANG;DREWE, WILLIAM C |