PHARMACEUTICAL FORMULATION COMPRISING NEUROKININ ANTAGONIST

摘要

Disclosed is a solid dispersion comprising (4R)-4-[N'-methyl-N'-(3,5-bistrifluoromethyl-benzoyl)-amino]-4-(3,4-dichlorobenzyl)-but-2-enoic acid N-[(R)-epsilon-caprolactam-3-yl]-amide or a pharmaceutically acceptable salt or solvate thereof, 5 and a carrier selected from hydroxypropylmethylcellulose with a low apparent dynamic viscosity from 0.01cps to 100cps, as measured at 20 degrees C for a 2 percent by weight aqueous solution, wherein the weight ratio carrier : pharmaceutically ingredient is 1:0.01 to 1:0.8. Also disclosed is a pharmaceutical composition comprising the solid dispersion described above and the process for making the solid dispersion. Further disclosed is a blister pack comprising the pharmaceutical composition and the use of the pharmaceutical composition in the manufacture of a medicament for treating gastrointestinal disorders, urinary bladder disorders or repertory disorders.