Antibiotika und Verfahren zu ihrer Herstellung

摘要

6 beta-Acylamido-penam-3 alpha-carboxylic acids and their non-toxic derivs. in which the acylamido gp. has the structure R-C(=N ORa)-CO-NH- (where R is H or an org. gp. and Ra is an etherified monovalent org. gp. linked to the O-atom via a C-atom), the cpd. being present as the syn or anti isomer or as a mixt. of these isomers, partic. cpds. of formula (I): (where B is S or SO), have antibacterial activity against gram-positive organisms as well as Haemophilus influenzae. The syn isomers are active against penicillinase-producing Staphylococci and are resistant to various beta-lactamases.