Antibacterial 7-aca derivs -7-heterocyclyl thioacetylamino - -cphalosporanic acid derivs

摘要

Novel cpds. of formula (I) (where R1 is a 5-membered heterocyclic residue contg. >=2 heteroatoms selecteds from N,O and S, opt. substd. by mercapto in the 5-posn. and opt. substd. in the other posns. by lower alkoxy, lower alkyl or OH, the heterocyclic gp. being bonded to the S atom of the mercapto gp. via a C atom positioned directly between 2 heteroatoms (e.g. 2-imidazolyl) and R2 is a quaternary amino gp.), claimed with their inner salts and having antibacterial activity against Gram +ve and Gran -ve bacteria, are prepd. by reacting a cpd. of formula (I); R2 is R3, in which R3 is an OH or SH gp. esterified with a (thio) carboxylic acid with a tert. amine.