Composition of osteogenic differentiation or osteogenesis comprising inhibitor of HVEM

摘要

PURPOSE: A composition containing HVEM inhibitors is provided to be used as a therapeutic agent for treating bone diseases. CONSTITUTION: A composition for promoting bone differentiation or osteogenesis contains HVEM(herpesvirus-entry mediator) gene expression inhibitor or HVEM protein activation inhibitor. The HVEM gene contains a base sequence of sequence number 1. The HVEM inhibitor is an antisense oligonucleotide, siRNA, or shRNA. A composition for preventing or treating bone diseases contains the composition as an active ingredient. A method for predicting or diagnosing risk of developing bone diseases comprises: a step of measuring HVEM gene expression level or HVEM protein level in a biological sample; and a step of comparing gene expression level or protein level between the biological sample and a control group.