Fremgangsmåde til at påvise polymorfi i ABCB1-genet associeret med mangel af respons for et CNS-aktivt lægemiddel samt lægemiddel omfattende en ABCB1-inhibitor til anvendelse i behandlingen af CNS-relaterede sygdomme

摘要

The present invention relates to methods, compositions and kits for determining the prognosis of a clinical response in a human patient to a medicament which acts in the central nervous system and which is a substrate of the ABCB1 protein. Further, the invention relates to a combination of medicaments for the treatment of human patients having specific polymorphisms in the ABCB1 gene.