| 发明名称 |
ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES |
| 摘要 |
The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
|
| 申请公布号 |
US2013144040(A1) |
申请公布日期 |
2013.06.06 |
| 申请号 |
US201213669230 |
申请日期 |
2012.11.05 |
| 申请人 |
GENENTECH, INC.;GENENTECH, INC. |
发明人 |
FUNG SEK CHUNG;LI KANG;LI YUCHENG;SINGH SANJAYA;ZHOU BIN-BING STEPHEN |
| 分类号 |
C07K16/18 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
