| 摘要 |
PROBLEM TO BE SOLVED: To provide a synthetic route for ivabradine in a high yield, which can eliminate the use of a hydride donor such as borohydride or noble metals such as a palladium catalyst, and which is useful in treatment and prevention of various kinds of clinical conditions of myocardial ischemia such as angina, myocardial infarction and rhythm disturbance associated with them, in various clinical conditions including the rhythm disturbance, particularly, supraventricular rhythm disturbance, and further in cardiac failure.SOLUTION: There are provided a process for synthesizing ivabradine represented by formula (I), an addition salt thereof with pharmaceutically acceptable acid, and a hydrate thereof. |
