| 摘要 |
[Object] To provide a method for accurately determining cerebral blood flows both in rest state and under medication with less invasive operations. [Solution] Cerebral blood flow is determined based on a formula represented by the following formulas (1) or (2) for a time under medication that continuously follows a resting time. B ( t ) = k 1 ⅇ - k 2 t 3 mC f ∫0 t 3 S ( tau ) ⅇ k 2 tau ⅆ tau ( ⅇ - k 2 d ( t - t 3 ) ) + k 1 d mC f ∫t 3 t ( S ( tau ) + S ( tau - t 3 ) ) · ⅇ - k 2 d · ( t - tau ) ⅆ tau ( t >= t 3 ) ( 1 )∫t 5 t 6 B ( t ) ⅆ t = k 1 k 2 d ⅇ - k 2 t 3 mC f ∫0 t 3 S ( tau ) ⅇ k 2 tau ⅆ tau · ( ⅇ - k 2 d ( t 5 - t 3 ) - ⅇ - k 2 d ( t 6 - t 3 ) ) +∫t 5 t 6 k 1 d mC f ∫t 3 t ( S ( tau ) + S ( tau - t 3 ) ) · ⅇ - k 2 d · ( t - tau ) ⅆ tau ⅆ t ( t >= t 3 ) ( 2 ) (B(t): the radiation count at the time of t, t3: the time when a radioisotope medicine is administered, t5: the time when acquisition of the imaging data started for the state under medication, t6: the time when acquisition of the imaging data finished for the state under medication, mCf: a scaling factor, k1: cerebral blood flow rest state, k2: the blood-outflow-rate-constant of brain tissues rest state, k1d: a cerebral blood flow under medication, and k2d: the blood-outflow-rate-constant of brain tissues under medication).
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