| 发明名称 |
SPIRO-OXINDOLE MDM2 ANTAGONISTS |
| 摘要 |
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases. |
| 申请公布号 |
US2014148494(A1) |
申请公布日期 |
2014.05.29 |
| 申请号 |
US201414170101 |
申请日期 |
2014.01.31 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN;SANOFI;ASCENTA LICENSING CORPORATION |
发明人 |
WANG SHAOMENG;ZHAO YUJUN;SUN WEI;KUMAR SANJEEV;LEOPOLD LANCE;DEBUSSCHE LAURENT;BARRIERE CEDRIC;CARRY JEAN-CHRISTOPHE;AMANING KWAME |
| 分类号 |
C07D487/10;A61K31/407;A61K45/06;A61N5/10 |
主分类号 |
C07D487/10 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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