| 主权项 |
1. A method of decreasing a patient's risk for developing coronary heart disease or having a recurrent cardiovascular event, comprising administering to the patient an effective amount of a compound of formula (I): wherein n, and m independently are integers from 2 to 9; each occurrence of R1, R2, R3, and R4 is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, or R1 and R2, taken together with the carbon to which they are attached, form a carbocyclic ring having from 3 to 6 carbons, or R3 and R4 together with the carbon to which they are attached, form a carbocyclic ring having from 3 to 6 carbons; Y1 and Y2 independently are —COOH, —CH2OH, tetrazole, and —COOR5; R5 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl; or an ester or a salt thereof, or a precursor thereof that metabolizes in vivo to the compound of formula (I) or the free acid, a salt, or a hydrate thereof,wherein the patient it on a stable dose of stain. |
