发明名称 |
Methods for Identifying and Treating an Individual with an Inflammatory Disease using Fatty Acid-Based Therapies |
摘要 |
The present invention provides methods of identifying a subject as responsive to treatment of an inflammatory disease and/or inflammation with one or more polyunsaturated fatty acids (PUFAs), comprising detecting, in a nucleic acid sample of a subject having an inflammatory disease and/or inflammation, the presence of a C allele at single nucleotide polymorphism (SNP) rs730012 in the leukotriene C4 synthase gene, wherein the presence of said C allele at rs730012 in said nucleic acid sample from the subject indicates that the subject is responsive to treatment of said inflammatory disease and/or inflammation with one or more PUFAs. |
申请公布号 |
US2015005382(A1) |
申请公布日期 |
2015.01.01 |
申请号 |
US201214367158 |
申请日期 |
2012.10.04 |
申请人 |
Wake Forest University Health Sciences (WFUHS) |
发明人 |
Chilton Floyd H. |
分类号 |
C12Q1/68;A61K36/30;A61K31/202 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
1. A method of identifying a subject as responsive to treatment of an inflammatory disease with one or more polyunsaturated fatty acids (PUFAs), comprising:
detecting, in a nucleic acid sample of a subject having an inflammatory disease, the presence of a C allele at single nucleotide polymorphism rs730012, wherein the presence of said C allele at rs730012 in said nucleic acid sample from the subject identifies the subject as being responsive to treatment of said inflammatory disease with one or more PUFAs. |
地址 |
Winston-Salem NC US |