DELIVERY OF THERAPEUTIC AGENTS USING OLIGONUCLEOTIDE-MODIFIED NANOPARTICLES AS CARRIERS

摘要

PROBLEM TO BE SOLVED: To provide delivery of therapeutic agents using oligonucleotide-modified nanoparticles as carriers.SOLUTION: Disclosed are drug delivery compositions comprising an oligonucleotide-modified nanoparticle and a therapeutic agent. Specifically, disclosed are compositions comprising a number of oligonucleotide molecules in a ratio to therapeutic agent molecules to allow a sufficient transportation of the therapeutic agent molecules into a cell. The therapeutic agents include both hydrophobic and hydrophilic agents. Different attachments of therapeutic agents in a composition are also described.