KITS FOR DIAGNOSTIC AND THERAPEUTIC USES OF AUGMENTER OF LIVER REGENERATION IN INFLAMMATORY CONDITIONS

摘要

The present invention provides for methods and kits for detecting sepsis, trauma/hemorrhage or inflammation in a subject. It is based, at least in part, on the discovery that Augmenter of Liver Regeneration (“ALR”) is an early marker of these conditions. Accordingly, in other embodiments, the present invention provides for a method of treating sepsis, traumatic/hemorrhagic shock and inflammation by inhibiting ALR.

主权项

1. A kit for detecting sepsis in a subject, comprising (i) a first antibody, or fragment thereof, which binds to Augmenter of Liver Regeneration (ii) a second antibody, which also binds to Augmenter of Liver Regeneration, linked to a detectable compound; and (iii) instructions that describe measuring the level of Augmenter of Liver Regeneration protein in a serum sample collected from a test human subject and comparing the level in the test subject to the serum level of Augmenter of Liver Regeneration protein in a healthy human control subject, wherein an elevation in the level of Augmenter of Liver Regeneration protein in the serum of the test subject compared with the control level is an indicator that the subject suffers from sepsis.