Modulation of insulin like growth factor I receptor expression in cancer

摘要

Provided herein are methods, compounds, and compositions for reducing expression of an IGF-IR mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions that inhibit expression of IGF-IR in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate the tumor or cancer, or a symptom thereof.

主权项

1. A method for enhancing the sensitivity of an IGF-IR positive tumor or cancer cell to a taxane based agent in a subject, the method comprising:
administering to a subject having a taxane based agent-resistant, IGF-IR positive tumor or cancer cell an effective amount of an agent that inhibits expression of IGF-IR.