DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF ISOFORM SELECTIVE ANALOGS OF LIPHAGANE SCAFFOLD AS ANSTICANCER AGENTS: P13K-ALPHA/BETA INHIBITORS

摘要

The analogs of meroterpenoid liphagane scaffold have been designed, synthesized and its biological evaluation results for anticancer activity by inhibiting PI3K pathway is presented in this invention. The field of invention for this work relates and covers the development of novel PI3K-α/ß inhibitors based on meroterpenoid liphagane scaffold for anticancer activity.