DIAGNOSING IDH1 RELATED SUBGROUPS AND TREATMENT OF CANCER

摘要

The invention relates to classification, diagnosis and treatment of cancers. In one embodiment, the present invention provides methods and kits that classify cancers into various subtypes based on expression patterns of AKT pathway components. In another embodiment, the present invention provides methods and kits that diagnose cancer subtypes by evaluating expression patterns of AKT pathway components. In still another embodiment, the present invention provides methods and kits that treat a cancer subtype by administering an alkylating agent or a PI3K/AKT/mTOR inhibitor to a patient. Cancers suitable with various embodiments of the invention include but are not limited to brain tumors, gliomas and GBM.

主权项

1. A method for treating, preventing, reducing the likelihood of having, reducing the severity of and/or slowing the progression of a cancer in a subject, comprising:
obtaining a sample from the subject; assaying the sample to detect increases and/or decreases in expression levels of AKT pathway components relative to reference samples or values; detecting an expression pattern of AKT pathway components in the sample based on the detected increases and/or decreases; and administering a therapeutically effective amount of a therapeutic to the subject, thereby treating, preventing, reducing the likelihood of having, reducing the severity of and/or slowing the progression of the cancer.