SALIVARY ESTRADIOL DETECTION METHODS AND USES FOR MONITORING OVULATION AND FERTILITY, AND SELECTION OR TIMING OF EGG RETRIEVAL AND/OR FERTILIZATION

摘要

This invention relates to methods to predict and monitor ovulation and fertility in female mammals by measuring the level of free salivary estradiol. Such information may be used to identify the appropriate timing for egg retrieval prior to in vitro fertilization (IVF), insemination procedures, natural or otherwise, and the timing for transfer of embryos. The ability to monitor salivary estradiol levels throughout the estrous cycle, with the optional application of an algorithm, will aid in identifying the peak time of fertility.

主权项

1. A method for stimulating production of eggs in a female mammal for in vitro fertilization, comprising,
a.) administering a hormone therapy that stimulates egg production in a female mammal, b.) obtaining or providing a saliva sample from the female mammal, c.) measuring the amount of estradiol in the saliva sample, d.) comparing the amount of saliva estradiol to a previously determined amount of estradiol from the female mammal in order to identify an increase in saliva estradiol, wherein an estradiol peak reflects increased egg production in the female mammal, thereby stimulating egg production in the female mammal for in vitro fertilization.