OIL-FREE AND FAT-FREE AQUEOUS SUSPENSIONS OF CYCLOSPORIN

摘要

Compositions that are oil-free and fat-free aqueous suspensions of cyclosporin and contain a cyclosporin (e.g., cyclosporine), a hydrophilic pharmaceutically acceptable solvent in which the cyclosporin (e.g., cyclosporine) is soluble, a dispersing agent, a suspending agent and an aqueous vehicle are disclosed. Methods of producing such compositions, as well as methods of using the compositions to treat ophthalmic disorders are also disclosed.

主权项

1. A composition comprising:
a) a cyclosporin; b) a hydrophilic pharmaceutically acceptable solvent; c) a dispersing agent; d) a suspending agent; and e) an aqueous vehicle, wherein the solvent, dispersing agent, suspending agent, and vehicle are each oil-free and fat-free, and wherein the composition is a suspension of cyclosporin, which suspension is formed by admixing a solution comprising the cyclosporin and the hydrophilic pharmaceutically acceptable solvent with a mixture of the dispersing agent, the suspending agent, and the aqueous vehicle, and wherein the suspension is oil-free and fat-free.