发明名称 |
Epigenetic markers of colorectal cancers and diagnostic methods using the same |
摘要 |
<p>The present invention relates generally to nucleic acid molecules in respect of which changes to DNA methylation levels are indicative of the onset or predisposition to the onset of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to DNA methylation levels are indicative of the onset and/or progression of a large intestine neoplasm, such as an adenoma or adenocarcinoma. The DNA methylation status of the present invention is useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal neoplasms, such as colorectal adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in DNA methylation of one or more nucleic acid molecules.</p> |
申请公布号 |
AU2015258259(A1) |
申请公布日期 |
2015.12.10 |
申请号 |
AU20150258259 |
申请日期 |
2015.11.19 |
申请人 |
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION;CLINICAL GENOMICS PTY. LTD |
发明人 |
ROSS, JASON PETER;DREW, HORACE;BUCKLEY, MICHAEL;MOLLOY, PETER LAURENCE;MITCHELL, SUSAN MARGARET;DUESING, KONSTA RAINER;XU, ZHENG-ZHOU |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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