C-TERMINAL AND CENTRAL EPITOPE A-BETA ANTIBODIES

摘要

The present invention provides antibodies directed against C-terminal and central epitopes of Aβ that preferentially bind compact plaques relative to diffuse plaques. The invention also provides methods of treating patients to reduce or eliminate the presence of compact plaques of Aβ and associated symptoms.

主权项

1. A method of treating a patient diagnosed with mid- or late-stage Alzheimer's disease, comprising administering to the patient an effective regime of an antibody that binds to an epitope within residues 12-43 of Aβ and preferentially binds compact plaques relative to diffuse plaques.